Journal
SCIENCE IMMUNOLOGY
Volume 1, Issue 1, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aag0851
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Funding
- NIH, National Institute of Allergy and Infectious Diseases, Division of AIDS
- UM-1 grant for the Duke Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery [AI100645]
- NIH [R21-AI100696, CHAVI-AI0678501]
- MRC Programme [MR/ K012037]
- MRC [MR/K012037/1] Funding Source: UKRI
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Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1- infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4(+) T cells, a higher frequency of circulating memory T follicular helper CD4(+) cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.
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