Journal
ANALYTICA CHIMICA ACTA
Volume 1032, Issue -, Pages 1-17Publisher
ELSEVIER
DOI: 10.1016/j.aca.2018.05.011
Keywords
Early diagnosis; Microbead array applications; Multiplexing; Biomarker; Cancer; Infectious disease; Neurological disease
Categories
Funding
- US NIH [R01AI050875, R21AI121700]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI121700, R01AI050875] Funding Source: NIH RePORTER
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Early diagnosis of diseases (before they become advanced and incurable) is essential to reduce morbidity and mortality rates. With the advent of novel technologies in clinical laboratory diagnosis, microbead-based arrays have come to be recognized as an efficient approach, that demonstrates useful advantages over traditional assay methods for multiple disease-related biomarkers. Multiplexed microbead assays provide a robust, rapid, specific, and cost-effective approach for high-throughput and simultaneous screening of many different targets. Biomolecular binding interactions occur after applying a biological sample (such as blood plasma, saliva, cerebrospinal fluid etc.) containing the target analyte(s) to a set of microbeads with different ligand-specificities that have been coded in planar or suspension arrays. The ligand-receptor binding activity is tracked by optical signals generated by means of flow cytometry analysis in the case of suspension arrays, or by image processing devices in the case of planar arrays. In this review paper, we discuss diagnosis of cancer, neurological and infectious diseases by using optically-encoded microbead-based arrays (both multiplexed and single-analyte assays) as a reliable tool for detection and quantification of various analytes. (C) 2018 Elsevier B.V. All rights reserved.
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