Journal
ANALYST
Volume 143, Issue 18, Pages 4316-4322Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an00567b
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Funding
- Science and Technology Basic Work of Science and Technology [2015FY111400]
- China National Major Scientific and Technological Special Project for Significant New Drugs Development [2018ZX09J18112]
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Contamination of freshwater with nodularin-R (NOD-R) represents a significant global environmental and public health concern. However, ethical problems and technical difficulties surrounding the current detection methods for NOD-R necessitate further studies to devise appropriate alternatives within a regulatory monitoring regime. In this work, we employed an aptamer as a specific recognition element and developed a biolayer interferometry (BLI) biosensor platform for NOD-R detection. The aptasensor we propose displayed a broad detection range from 40 to 600 nM NOD-R (and a linear response range from 40 to 200 nM), and achieved a detection limit as low as 167 pM. In addition, the aptamer-based biosensor was shown to possess high selectivity, as well as good reproducibility and stability. We believe that this novel aptamer-based biosensor provides a potential alternative for the sensitive and rapid detection of NOD-R.
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