Journal
ANALYST
Volume 143, Issue 11, Pages 2555-2562Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an00556g
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Funding
- Research Foundation of Jiangsu University [11JDG078]
- National Natural Science Foundation of China [21202063]
- Natural Science Foundation of Jiangsu Province [BK2012281]
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Labile Fe2+ has been considered to be a metabolically active and regulatory form of cellular iron. Monitoring the dynamic level of labile Fe2+ in biological systems is vital for evaluating the iron related biological processes and diseases as well as dissecting the exact physiological and pathophysiological functions of the labile Fe2+. Herein, we rationally constructed a coumarin-based fluorescent probe for sensing labile Fe2+ in living systems based on a novel Fe2+ meditated cyclization reaction strategy. The probe showed a highly selective and sensitive response to Fe2+, and the detection limit was determined to be 45 nM. Significantly, the probe displayed fast response to Fe2+, with the sensing reaction completed in 2 min, which is beneficial for real time sensing. The application of the probe for sensing different concentrations of labile Fe2+ in living cells has been conducted. In addition, the basal and endogenous levels of labile Fe2+ in living systems were also successfully monitored.
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