4.3 Review

Enhancer-associated RNAs as therapeutic targets

Related references

Note: Only part of the references are listed.
Editorial Material Genetics & Heredity

What are super-enhancers?

Sebastian Pott et al.

NATURE GENETICS (2015)

Article Biochemistry & Molecular Biology

B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity

Jason Qian et al.

Article Biochemistry & Molecular Biology

Enhancer RNA Facilitates NELF Release from Immediate Early Genes

Katie Schaukowitch et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

An atlas of active enhancers across human cell types and tissues

Robin Andersson et al.

NATURE (2014)

Article Biochemistry & Molecular Biology

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

Tomohiko Kanno et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

Chen-Lin Hsieh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Jakob Loven et al.

Letter Biochemistry & Molecular Biology

DNA Methylation of Transcriptional Enhancers and Cancer Predisposition

Dvir Aran et al.

Article Biochemistry & Molecular Biology

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte et al.

Article Biochemistry & Molecular Biology

Super-Enhancers in the Control of Cell Identity and Disease

Denes Hnisz et al.

Article Biochemistry & Molecular Biology

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

Priti Anand et al.

Article Biochemistry & Molecular Biology

Enhancer transcripts mark active estrogen receptor binding sites

Nasun Hah et al.

GENOME RESEARCH (2013)

Article Biochemistry & Molecular Biology

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

Carlos A. Melo et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci

Kambiz Mousavi et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Effect of natural genetic variation on enhancer selection and function

S. Heinz et al.

NATURE (2013)

Article Multidisciplinary Sciences

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Michael T. Y. Lam et al.

NATURE (2013)

Article Biotechnology & Applied Microbiology

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

Seung Woo Cho et al.

NATURE BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang et al.

NATURE BIOTECHNOLOGY (2013)

Editorial Material Medicine, General & Internal

Micromanaging Hepatitis C Virus

Judy Lieberman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Treatment of HCV Infection by Targeting MicroRNA

Harry L. A. Janssen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong et al.

SCIENCE (2013)

Review Oncology

Forkhead box proteins: tuning forks for transcriptional harmony

Eric W. -F. Lam et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

Panagis Filippakopoulos et al.

Article Multidisciplinary Sciences

In vivo genome editing using a high-efficiency TALEN system

Victoria M. Bedell et al.

NATURE (2012)

Article Multidisciplinary Sciences

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham et al.

NATURE (2012)

Article Multidisciplinary Sciences

The accessible chromatin landscape of the human genome

Robert E. Thurman et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon et al.

NATURE BIOTECHNOLOGY (2012)

Review Genetics & Heredity

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

Karen Adelman et al.

NATURE REVIEWS GENETICS (2012)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

Matthew T. Maurano et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E. Delmore et al.

Article Biochemistry & Molecular Biology

H3K4 tri-methylation provides an epigenetic signature of active enhancers

Aleksandra Pekowska et al.

EMBO JOURNAL (2011)

Review Cell Biology

Pioneer transcription factors: establishing competence for gene expression

Kenneth S. Zaret et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

Aurelien A. Serandour et al.

GENOME RESEARCH (2011)

Article Multidisciplinary Sciences

A unique chromatin signature uncovers early developmental enhancers in humans

Alvaro Rada-Iglesias et al.

NATURE (2011)

Article Multidisciplinary Sciences

Mapping and analysis of chromatin state dynamics in nine human cell types

Jason Ernst et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters

Frederic Koch et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Long Noncoding RNAs with Enhancer-like Function in Human Cells

Ulf Andersson Orom et al.

Article Multidisciplinary Sciences

Widespread transcription at neuronal activity-regulated enhancers

Tae-Kyung Kim et al.

NATURE (2010)

Article Multidisciplinary Sciences

Suppression of inflammation by a synthetic histone mimic

Edwige Nicodeme et al.

NATURE (2010)

Article Multidisciplinary Sciences

Selective inhibition of BET bromodomains

Panagis Filippakopoulos et al.

NATURE (2010)

Article Genetics & Heredity

Nucleosome dynamics define transcriptional enhancers

Housheng Hansen He et al.

NATURE GENETICS (2010)

Review Biotechnology & Applied Microbiology

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

Aimee L. Jackson et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Multidisciplinary Sciences

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers

Francesca De Santa et al.

PLOS BIOLOGY (2010)

Article Multidisciplinary Sciences

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Nathaniel D. Heintzman et al.

NATURE (2009)

Review Multidisciplinary Sciences

Finding the missing heritability of complex diseases

Teri A. Manolio et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

High-resolution profiling of histone methylations in the human genome

Artern Barski et al.

Review Biochemistry & Molecular Biology

Controlling the elongation phase of transcription with P-TEFb

B. Matija Peterlin et al.

MOLECULAR CELL (2006)

Article Multidisciplinary Sciences

Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

SCIENCE (2005)

Review Genetics & Heredity

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn et al.

NATURE REVIEWS GENETICS (2005)

Article Biochemistry & Molecular Biology

Antiproliferative effects of steric blocking phosphorodiamidate morpholino antisense agents directed against c-myc

RM Hudziak et al.

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT (2000)