Journal
ANALYST
Volume 143, Issue 9, Pages 2042-2050Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7an01883e
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Funding
- Polish Ministry of Science and Higher Education [IP2015 048474]
- National Centre for Research and Development (the project METENDOPHA) [STRATEGMED1/233226/11/NCBR/2015]
- Kosciuszko Fellowship
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The combination of FT-IR and Raman spectroscopies allowed the biochemical profiling of lungs in the early stage of pulmonary metastasis in the murine model of breast cancer. Histological staining was used as a reference. Raman spectroscopy was especially useful in the detection and semi-quantitative analysis of the vitamin A content in lung lipofibroblasts, whereas the IR technique provided semi-quantitative information on the contents of nucleic acids, carbohydrates including glycogen, and lipids as well as changes in the secondary structures of tissue proteins. Our spectroscopic results suggest that the early phase of metastasis in the lung is characterized by a decrease in the endogenous retinoid content in combination with a decrease in the content of glycogen and lipids.
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