Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 2, Issue 4, Pages 429-438Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2016.05.001
Keywords
Adaptation; Epithelium; Angiogenesis; Absorption; Villus; Apoptosis; Proliferation; Growth Factors
Categories
Funding
- National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases [DK059288, DK104698]
- March of Dimes
- St. Louis Children's Hospital Foundation-Children's Surgical Sciences Research Institute
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After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process.
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