Journal
AMINO ACIDS
Volume 50, Issue 9, Pages 1301-1305Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-018-2600-0
Keywords
Fluciclovine; Prostate cancer; PC3; Amino acid transport; Axumin
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Funding
- Cancer Animal Models Shared Resource
- Winship Cancer Institute of Emory University
- Cancer Center Support Grant [P30 CA138292]
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We investigated if previously demonstrated inhibition of fluciclovine (F-18) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (+/- 5.4)% and 25.3 (+/- 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.
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