Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 18, Issue 5, Pages 1270-1274Publisher
WILEY
DOI: 10.1111/ajt.14737
Keywords
clinical research; practice; obstetrics and gynecology; quality of life (QOL); reproductive biology; vascularized composite and reconstructive transplantation
Categories
Ask authors/readers for more resources
Uterus transplantation has proven to be a successful treatment for women with absolute uterine infertility, caused either by the absence of a uterus or the presence of a nonfunctioning uterus. We report the first birth of a healthy child following uterus transplantation in the United States, from a recipient of a uterus allograft procured from an altruistic living donor. Two major modifications from the previously reported live births characterized this uterus transplant. First, the transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow. The implication is a significantly simplified living donor surgery that paves the way for minimally invasive laparoscopic or robot-assisted techniques for the donor hysterectomy. Second, the time from transplantation to embryo transfer was significantly shortened from prior protocols, allowing for an overall shorter exposure to immunosuppression by the recipient and lowering the risk for potential adverse effects from these medications. Testa etal report the first live birth in the United States after uterus transplantation, with two major modifications from the previously reported live births: The transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow, and the time from transplantation to embryo transfer was significantly shortened from prior protocols.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available