Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 79, Issue 6, Pages -Publisher
WILEY
DOI: 10.1111/aji.12838
Keywords
oligoasthenoteratozoospermia; seminal hyperviscosity; seminal microbiome; urogenital infections
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Funding
- Programa Operacional Regional do Norte (Norte 2020) [NORTE-01-0145-FEDER-000029]
- Fundacao para a Ciencia e a Tecnologia (FCT) [PEst-C/SAU/LA0003/2013, POCI-01-0145-FEDER-007274, PTDC/BEX-GMG/0242/2012]
- European Social Funds (COMPETE-FEDER)
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Problem: Sexually transmitted diseases and other infections of male genitourinary tract are thought to negatively impact reproductive health, affecting semen quality. Despite a possible link between bacteria and infertility, few studies attempted to characterize seminal microbiota in healthy and diseased subjects. Methods of the study: A high-throughput sequencing of 16S ribosomal RNA gene was performed in a cohort of infertility-related cases (N = 89) and controls (N = 29) using a pooled sample approach. Results: A global characterization of microbiota was obtained at low cost, without compromising the identification of bacterial taxa. This strategy allowed us to detect changes in the microbiota of infertility-related phenotypes, such as an increment of Proteobacteria in seminal hyperviscosity, and to separate this later group from oligoasthenoteratozoospermia based in bacterial (family/genus) abundances. Conclusion: We provide data for a likely contribution of bacteria into seminal hyperviscosity and oligoasthenoteratozoospermia, partially correlated with an increment of Neisseria, Klebsiella, and Pseudomonas pathogens and a reduction in Lactobacillus probiotic agent.
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