Journal
BIOMEDICAL MATERIALS
Volume 11, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-6041/11/3/031001
Keywords
bladder regeneration; bladder acellular matrix (BAM); adipose-derived mesenchymal stem cells; tissue regeneration
Funding
- National Natural Science Foundation of China [31300806, 81470926]
- Chinese Academy of Sciences [ZDRW-ZS-2016-2]
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Tissue engineering brings new hope for the reconstruction of injured bladders. The aim of the present study was to evaluate human adipose-derived mesenchymal stem cells (hADSCs) combined with a bladder acellular matrix (BAM) for bladder regeneration. A BAM or BAM loaded with hADSCs (BAM/hADSCs) was used to repair partial cystectomy of the bladder in a canine model. 6 months after implantation, calculi and urine leakage were not found in either the BAM or BAM/hADSCs group by cystography. And compared to the BAM group, a significant increase of maximum bladder volume and bladder compliance was observed in the BAM/hADSCs group by urodynamics evaluation. Moreover, histological analysis showed that the BAM/hADSCs group could more effectively promote the regeneration of bladder smooth muscle and vascularization than the BAM group. These results demonstrated that a BAM/hADSCs could be an effective approach to promote bladder reconstruction with potential clinical applications.
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