4.5 Review

A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00150.2018

Keywords

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Funding

  1. Heart and Stroke Foundation of Canada [G-16-00013171]
  2. Deutsche Forschungsgesellschaft [KU1218/9-1]
  3. Deutsche Zentrum fur Herz-Kreislauf-Forschung e. V.
  4. Deutsches Zentrum fuer Lungenforschung
  5. Ontario Research Excellence Fund SCORR [RE07-086]
  6. National Heart, Lung, and Blood Institute (NHLBI) [HL122887, HL014985, HL125739, HL120001, HL138473]
  7. Oesterreichische Nationalbank [16682]
  8. Oesterreichischer Auslandsdienst fuer Wissenschaftlich-Technische Zusammenarbeit [Hu07/2016]
  9. International Ph.D. Program University of Graz
  10. Japan Society for the Promotion Science [26461146, 17K09591]
  11. NHLBI [R01 HL074186, R01 HL087118, R01 HL122887, R01 HL138473, P01 HL108797, R24 HL123767, K12 HL120001, R01 HL124021, HL122596, HL138437, RO1-HL071115, 1RC1HL099462, R01 HL128734]
  12. National Center for Advancing Translational Sciences [UH2 TR00-2073]
  13. American Heart Association Established Investigator Award [18EIA33900027]
  14. Canadian Institutes of Health Research (CIHR) Foundation Award [FDN_143291]
  15. Ontario Research Excellence Fund (ORF) [RE07-086]
  16. British Heart Foundation Chair of Cardiopulmonary Medicine
  17. CIHR Foundation
  18. Canada Research Chair in Mitochondrial Dynamics
  19. William J. Henderson Foundation
  20. CIHR Vascular Network
  21. Canadian Vascular Network
  22. Department of Defense [PR161256]
  23. Wall Center for Pulmonary Vascular Disease Stanford
  24. Pulmonary Hypertension Association Career Development Grant
  25. MRC [MR/K020919/1] Funding Source: UKRI
  26. Grants-in-Aid for Scientific Research [26461146, 17K09591] Funding Source: KAKEN

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The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.

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