Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 315, Issue 3, Pages H540-H549Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00117.2018
Keywords
artery layers; artery tissue modeling; artery wall biomechanics; artery wall micro-structure; passive-active modeling
Funding
- EPSRC [EP/N014642/1] Funding Source: UKRI
- MRC [MC_PC_17178] Funding Source: UKRI
- Medical Research Council [MC_PC_17178] Funding Source: Medline
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The microstructure of arteries, consisting, in particular, of collagen, elastin, and vascular smooth muscle cells, plays a very significant role in their biomechanical response during a cardiac cycle. In this article, we highlight the microstructure and the contributions of each of its components to the overall mechanical behavior. We also describe the changes of the microstructure that occur as a result of abdominal aortic aneurysms and disease, such as atherosclerosis. We also focus on how the passive and active constituents are incorporated into a mathematical model without going into detail of the mathematical formulation. We conclude by mentioning open problems toward a better characterization of the biomechanical aspects of arteries that will be beneficial for a better understanding of cardiovascular pathophysiology.
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