4.6 Review

Extracellular adenosine: a critical signal in liver fibrosis

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00006.2018

Keywords

extracellular adenosine; G protein-coupled receptor; hepatic fibrosis; liver myofibroblasts; purinergic signaling

Funding

  1. Gilead Sciences Research Scholars Program in Liver Disease Award [UAMS 271G141616-01]

Ask authors/readers for more resources

Extracellular adenosine nucleoside is a potent, endogenous mediator that signals through specific G protein-coupled receptors, and exerts pleiotropic effects on liver physiology, in health and disease. Particularly, adenosinergic or adenosine-mediated signaling pathways impact the progression of hepatic fibrosis, a common feature of chronic liver diseases, through regulation of matrix deposition by liver myofibroblasts. This review examines the current lines of evidence on adenosinergic regulation of liver fibrosis and myofibroblasts, identifies unanswered research questions, and proposes important future areas of investigation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available