Journal
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Volume 315, Issue 1, Pages G12-G19Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00006.2018
Keywords
extracellular adenosine; G protein-coupled receptor; hepatic fibrosis; liver myofibroblasts; purinergic signaling
Categories
Funding
- Gilead Sciences Research Scholars Program in Liver Disease Award [UAMS 271G141616-01]
Ask authors/readers for more resources
Extracellular adenosine nucleoside is a potent, endogenous mediator that signals through specific G protein-coupled receptors, and exerts pleiotropic effects on liver physiology, in health and disease. Particularly, adenosinergic or adenosine-mediated signaling pathways impact the progression of hepatic fibrosis, a common feature of chronic liver diseases, through regulation of matrix deposition by liver myofibroblasts. This review examines the current lines of evidence on adenosinergic regulation of liver fibrosis and myofibroblasts, identifies unanswered research questions, and proposes important future areas of investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available