Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 315, Issue 1, Pages E7-E14Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00473.2017
Keywords
Alzheimer's disease; estrogens; fatty acid oxidation; fatty acids; sexual dimorphism
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Funding
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1160820, 1171075]
- FONDAP-ACCD [15130011]
- CONICYT [PCI 170147]
- International Centre for Genetic Engineering and Biotechnology Grant [CRP/CHL16-06]
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Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.
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