Journal
JOURNAL OF BREATH RESEARCH
Volume 10, Issue 3, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1752-7155/10/3/034001
Keywords
proteomics; lung cancer; exhaled breath condensate; biomarker discovery; NSCLC
Categories
Funding
- Cancer Institute New South Wales
- Swiss National Science Foundation [P300P3_155328]
- Swiss National Science Foundation (SNF) [P300P3_155328] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Lung cancer is a leading cause of cancer-related deaths worldwide, and is considered one of the most aggressive human cancers, with a 5 year overall survival of 10-15%. Early diagnosis of lung cancer is ideal; however, it is still uncertain as to what technique will prove successful in the systematic screening of high-risk populations, with the strongest evidence currently supporting low dose computed tomography (LDCT). Analysis of exhaled breath condensate (EBC) has recently been proposed as an alternative low risk and non-invasive screening method to investigate early-stage neoplastic processes in the airways. However, there still remains a relative paucity of lung cancer research involving EBC, particularly in the measurement of lung proteins that are centrally linked to pathogenesis. Considering the ease and safety associated with EBC collection, and advances in the area of mass spectrometry based profiling, this technology has potential for use in screening for the early diagnosis of lung cancer. This review will examine proteomics as a method of detecting markers of neoplasia in patient EBC with a particular emphasis on LC, as well as discussing methodological challenges involving in proteomic analysis of EBC specimens.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available