Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 219, Issue 2, Pages -Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2018.05.034
Keywords
diet; endometriosis; meat
Categories
Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [HD4854, HD52473, HD57210]
- National Institute of Diabetes and Digestive and Kidney Diseases [P30 DK046200]
- Public Health Service grant from the National Cancer Institute (NCI), National Institutes of Health (NIH), US Department of Health and Human Services [UM1 CA176726]
- NCI, NIH [K22 CA193860]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD057210] Funding Source: NIH RePORTER
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R03HD048544, R01HD052473] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [UM1CA176726, K22CA193860] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [TL1TR001883] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK046200] Funding Source: NIH RePORTER
Ask authors/readers for more resources
BACKGROUND: Only 2 case-control studies have examined the associations between consumption of meat products and endometriosis risk with inconsistent results. Consumption of animal products has the potential to influence endometriosis risk through effects on steroid hormones levels. OBJECTIVE: We sought to determine whether higher intake of red meat, poultry, fish, and seafood are associated with risk of laparoscopically confirmed endometriosis. STUDY DESIGN: A total of 81,908 participants of the prospective Nurses' Health Study II were followed up from 1991 through 2013. Diet was assessed via food frequency questionnaire every 4 years. Cox proportional hazards models were used to calculate rate ratios and 95% confidence intervals. RESULTS: During 1,019,294 person-years of follow-up, 3800 cases of incident laparoscopically confirmed endometriosis were reported. Women consuming > 2 servings/d of red meat had a 56% higher risk of endometriosis (95% confidence interval, 1.22-1.99; P-trend <.0001) compared to those consuming <= 1 serving/wk. This association was strongest for non-processed red meats (rate ratio, 1.57; 95% confidence interval, 1.35-1.83 for >= 2 servings/d vs <= 1 servings/wk; P-trend <.0001), particularly among women who had not reported infertility (P-interaction =.0004). Women in the highest category of processed red meat intake also had a higher risk of endometriosis (rate ratio, 1.20; 95% confidence interval, 1.06-1.37 for >= 5 servings/wk vs < 1 serving/mo; P-trend =.02). Intakes of poultry, fish, shellfish, and eggs were unrelated to endometriosis risk. CONCLUSION: Our prospective analysis among premenopausal US nurses suggests that red meat consumption may be an important modifiable risk factor for endometriosis, particularly among women with endometriosis who had not reported infertility and thus were more likely to present with pain symptoms. Well-designed dietary intervention studies among women with endometriosis could help confirm this observation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available