Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms17060957
Keywords
exosomes; extracellular vesicles; aquaporin-1; aquaporin-2; kidney; urine
Funding
- JSPS KAKENHI [25660241, 15H04594, 25221205, 15K18784]
- Grants-in-Aid for Scientific Research [25660241, 15K18784, 15H04594] Funding Source: KAKEN
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Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper's group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.
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