Journal
EXPERIMENTAL NEUROLOGY
Volume 272, Issue -, Pages 97-108Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2015.05.006
Keywords
Vascular dementia; Cognition; Multiple infarct dementia; High fat diet; Treatment
Categories
Funding
- National Institute of Neurological Disorders and Stroke [RO1 NS083078, 41NS064708]
- National Institute on Aging [RO1 AG037506]
- American Heart Association [14GRNT20460026]
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Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options. (C) 2015 Elsevier Inc. All rights reserved.
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