Journal
EXPERIMENTAL NEUROLOGY
Volume 263, Issue -, Pages 285-292Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2014.10.021
Keywords
Adult neurogenesis; Granule neurons; CA2; Retrovirus; Mossy fiber terminal
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Funding
- Spanish Ministry of Health [SAF 2006-02424, BFU-2008-03980, BFU-2010-21507]
- Comunidad de Madrid [SAL/0202/2006]
- Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII) [CB401]
- Fundacion R Areces
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Newborn neurons are continuously added to the hippocampal dentate gyrus (DG) throughout life. Mature and immature granule neurons are believed to send their axonal projections exclusively to the hippocampal CA3 field. However, recent data point to an alternative trisynaptic circuit, involving a direct axonal projection from mature granule neurons to the CA2 field. Whether this circuit takes place only in mature granule neurons or, on the contrary, whether immature granule neurons also contribute to this novel connection is unknown. We used various retroviral vectors to show that immature granule neurons send axonal processes to and establish synaptic contacts with CA2 pyramidal neurons and that axonal growth follows a similar time course to that described for CA3 innervation. In addition, we provide experimental evidence demonstrating that the pathway connecting newborn granule neurons and the CA2 field can be modulated by physiological and deleterious stimuli. (C) 2014 Elsevier Inc All rights reserved.
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