Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 37, Pages 20845-20854Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b06128
Keywords
chitosan; 45S5 bioactive glass; PHBV microsphere; drug delivery; membrane; guided bone regeneration
Funding
- China Scholarship Council (CSC) [2011628002, 2011628003]
- Zhejiang National Nature Science Foundation [LQ15H180003]
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Novel multifunctional chitosan-45S5 bioactive glass-poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microsphere (CS-BG-MS) composite membranes were developed with applicability in guided tissue/bone regeneration (GTR/GBR). The incorporation of 45S5 BG and PHBV MS into CS membranes not only provided the membranes with favorable surface roughness, hydrophilicity, and flexibility but also slowed down their degradation rate. Moreover, the CS membranes became bioactive after the incorporation of 45S5 BG and capable of releasing drugs of different physicochemical properties in a controlled and sustained manner with the addition of PHBV MS. Cell culture tests showed that osteoblast-like MG-63 human osteosarcoma cells had significantly higher adhesion, cell proliferation, and alkaline phosphatase (ALP) activity on CS-BG and CS-BG-MS membranes than on neat CS membranes. Therefore, the developed bioactive CS-BG-MS membranes with potential multidrug (e.g., antibacterial and antiosteoporosis drugs) delivery capability are promising candidate membranes for GTR/GBR applications.
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