Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms17050638
Keywords
cancer; cell fusion; metastasis; drug resistance; syncytin
Funding
- Swiss National Science Foundation [31003A_163395]
- Fondation pour la lutte contre le cancer
- Swiss National Science Foundation (SNF) [31003A_163395] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available