Journal
AMERICAN JOURNAL OF HUMAN BIOLOGY
Volume 30, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/ajhb.23127
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Funding
- Ministry of Health, Labour and Welfare
- Health and Labour Sciences Research Grants
- Japan Society for the Promotion of Science
- Environment Research and Technology Development Fund from the Ministry of the Environment, Japan [5C-1252]
- Grants-in-Aid for Scientific Research [15K15220, 15K20825] Funding Source: KAKEN
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ObjectivesWe investigated the relationship between steroid hormone levels in cord blood and birth weight. MethodsAmong 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. ResultsAndrostenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females. ConclusionsPrenatal adrenal steroids as well as converting enzymes such as 11 ss-hydrosteroid dehydrogenase type 2 and 3 ss-hydrosteroid dehydrogenase may have an impact on prenatal physical development.
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