Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms17081307
Keywords
serum and glucocorticoid regulated kinase 1 (SGK1); epithelial sodium channels; voltage-gated sodium channels; hypertension; edema; heart disease; embryo implantation
Funding
- National Basic Research Program of China [2014CB943302, 2012CB944901]
- National Natural Science Program of China [81571500, 81370760]
- Natural Science Program of Zhejiang Province, China [Y2100822]
- Zhejiang Provincial Natural Science Foundation of China [LZ13H040001, LZ15H040001]
- Medical Scientific Research Program of Zhejiang Province [2014KYA269, 2016KYA120]
- Health Science and Technology Program of Hangzhou [2014A54]
- Traditional Chinese medicine Program of Zhejiang Province [2015ZA159]
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The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly regulated by osmotic and hormonal signals, including glucocorticoids and mineralocorticoids. Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) and type A natriuretic peptide receptor (NPR-A). Accordingly, SGK1 is implicated in the physiology and pathophysiology of Na+ homeostasis. Here, we focus particularly on recent findings of SGK1's involvement in Na+ transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance and discuss the abnormal SGK1-mediated Na+ reabsorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure.
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