Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms17081232
Keywords
allotransplantation; biomarker; immune rejection; miRNA; circulating; xenotransplantation
Funding
- Project of Shenzhen Engineering Center [GCZX2015043017281705]
- Clinical Doctor-Basic Scientist Combination Foundation of Shenzhen Second People's Hospital
- Key Laboratory Project of Shenzhen Second People's Hospital
- Shenzhen Foundation of Science and Technology [GJHZ20140414170821192, JCYJ20140414170821337, JCYJ20160229204849975]
- 'Three Outstanding Projects' of Shenzhen
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Different cell types possess differentmiRNA expression profiles, and cell/tissue/organ-specific miRNAs (or profiles) indicate different diseases. Circulating miRNA is either actively secreted by living cells or passively released during cell death. Circulating cell/tissue/organ-specific miRNA may serve as a non-invasive biomarker for allo-or xeno-transplantation to monitor organ survival and immune rejection. In this review, we summarize the proof of concept that circulating organ-specific miRNAs serve as non-invasive biomarkers for a wide spectrum of clinical organ-specific manifestations such as liver-related disease, heart-related disease, kidney-related disease, and lung-related disease. Furthermore, we summarize how circulating organ-specific miRNAs may have advantages over conventional methods for monitoring immune rejection in organ transplantation. Finally, we discuss the implications and challenges of applying miRNA to monitor organ survival and immune rejection in allo-or xeno-transplantation.
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