Journal
ALZHEIMERS & DEMENTIA
Volume 14, Issue 2, Pages 195-204Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.08.014
Keywords
Longevity; Insulin signaling; Alzheimer's pathology; Animal models; Tau; Amyloid; GSK-3
Categories
Funding
- NIHR
- MRC
- ARUK
- Alzheimer's Society
- Wellcome Trust
- EU
- Parkinson"
- s UK [J-1403] Funding Source: researchfish
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Introduction: Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. They may also be linked by the remarkable observation that insulin signaling sets the limits on longevity. In worms, flies, and mice, disrupting insulin signaling increases life span leading to speculation that caloric restriction might extend life span in man. It is our contention that man is already a long-lived organism, specifically with a remarkably high postfertility life span, and that it is this that results in the prevalence of Alzheimer's disease and diabetes. Methods: We review evidence for this hypothesis that carries specific predictions including that other animals with exceptionally long postreproductive life span will have increased risk of both diabetes and Alzheimer's disease. Results and Conclusions: We present novel evidence that Dolphin, like man, an animal with exceptional longevity, might be one of the very few natural models of Alzheimer's disease. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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