Journal
ALZHEIMERS & DEMENTIA
Volume 14, Issue 4, Pages 454-461Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.10.007
Keywords
Sleep hygiene; Socioeconomic factors; Cognitive dysfunction; Cognitive decline; Cohort study; APOE
Categories
Funding
- NIA [R01 AG042633]
- National Institute on Aging (NIA) [U01AG009740]
- Social Security Administration
- Zinfandel Pharmaceutics
- Cabernet Pharmaceutics
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Introduction: We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. Methods: Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multiple biennial cognitive observations (abbreviated Telephone Interview for Cognitive Status), were included. Participants were grouped into quartiles of NSES and sleep quality scores. We adjusted for apolipoprotein E epsilon 4, demographic, and cardiovascular risk factors. Random effects modeling evaluated cognitive change over time. Results: NSES and sleep were significantly associated with cognitive decline, and there was a significant interaction between them (P=.02). Significant differences between high/low NSES and high/low sleep quality (P<.0001) were found. Discussion: Sleep and NSES were associated with cognitive decline; the association between sleep and cognition appeared stronger among those with low NSES. The association between low NSES, poor sleep quality, and cognitive decline was roughly equivalent to the association between apolipoprotein E epsilon 4 and cognitive decline. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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