Journal
ALZHEIMERS & DEMENTIA
Volume 14, Issue 4, Pages 502-513Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2018.01.011
Keywords
Amyloid beta; Presynaptic terminal; SNARE complex; Exocytosis; Transmitter release; Neuromodulation
Categories
Funding
- Higher Education Authority of Ireland
- Neuroscience Section Grant for Target-Driven Therapeutics and Theranostics Research
Ask authors/readers for more resources
The synaptic vesicle cycle (SVC) holds center stage in the biology of presynaptic terminals. Through recurrent exocytosis and endocytosis, it facilitates a sequence of events enabling chemical neurotransmission between functionally related neurons. As a fundamental process that links the interior of nerve cells with their environment, the SVC is also critical for signaling and provides an entry route for a range of pathogens and toxins, enabling detrimental effects. In Alzheimer's disease, the SVC is both the prime site of amyloid beta production and toxicity. In this study, we discuss the emerging evidence for physiological and pathological effects of A beta on various stages of the SVC, from postfusion membrane recovery to trafficking, docking, and priming of vesicles for fusion and transmitter release. Understanding of the mechanisms of A beta interaction with the SVC within the unifying calcium hypothesis of aging and Alzheimer's disease should further elucidate the fundamental biology of the presynaptic terminal and reveal novel therapeutic targets for Alzheimer's disease and other age-related dementias. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available