Journal
EXPERIMENTAL GERONTOLOGY
Volume 68, Issue -, Pages 76-81Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2014.10.002
Keywords
Aging; Brain; Neuroendocrine; IGF-1; GH
Categories
Funding
- National Institute on Aging [AG038747, AG048728]
- Oklahoma Center for the Advancement of Science and Technology
- Ellison Medical Foundation
- OAIC grant [P30 AG028718]
- [NS056218]
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Growth hormone (GH) and insulin-like growth factor (IGF)-1 regulate the development and function of cells throughout the body. Several clinical diseases that result in a decline in physical and mental functions are marked by mutations that disrupt GH or IGF-1 signaling. During the lifespan there is a robust decrease in both GH and IGF-1. Because GH and IGF-1 are master regulators of cellular function, impaired GH and IGF-1 signaling in aging/disease states leads to significant alterations in tissue structure and function, especially within the brain. This review is intended to highlight the effects of the GH and IGF-1 on neuronal structure, function, and plasticity. Furthermore, we address several potential mechanisms through which the age-related reductions in GH and IGF-1 affect cognition. Together, the studies reviewed here highlight the importance of maintaining GH and IGF-1 signaling in order to sustain proper brain function throughout the lifespan. (C) 2014 Elsevier Inc. All rights reserved.
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