Journal
EXPERIMENTAL EYE RESEARCH
Volume 133, Issue -, Pages 3-18Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2015.02.017
Keywords
Retina; Photoreceptor cell; Interphotoreceptor matrix; lnterphotoreceptor retinoid binding protein; Proteoglycans; Growth factors; Inherited retinal degenerative disorders; Age-related macular degeneration
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Funding
- JSPS KAKENHI [24592666]
- Grants-in-Aid for Scientific Research [24592666] Funding Source: KAKEN
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The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions. (C) 2015 The Authors. Published by Elsevier Ltd.
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