Journal
EXPERIMENTAL EYE RESEARCH
Volume 141, Issue -, Pages 9-14Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2015.06.020
Keywords
Glaucoma; Microbead; Animal model; Rodent; Primate
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The sustained and moderate elevation of intraocular pressure, which can be initiated at precise time points, remains the cornerstone of research into the mechanisms of glaucomatous retinal damage. We focus on the use of microbeads to block the outflow of aqueous following anterior chamber injection in a range of animals (mouse, rat and primate). We describe some of the most commonly used parameters and present guidance on injection technique and bead manipulation to facilitate the successful generation of experimental glaucoma. (C) 2015 Elsevier Ltd. All rights reserved.
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