Journal
VACCINES
Volume 4, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/vaccines4030023
Keywords
interferon; viruses; immune evasion; JAK/STAT pathway; vaccines; innate immunity
Categories
Ask authors/readers for more resources
The interferon (IFN) induced anti- viral response is amongst the earliest and most potent of the innate responses to fight viral infection. The induction of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) signalling pathway by IFNs leads to the upregulation of hundreds of interferon stimulated genes (ISGs) for which, many have the ability to rapidly kill viruses within infected cells. During the long course of evolution, viruses have evolved an extraordinary range of strategies to counteract the host immune responses in particular by targeting the JAK/STAT signalling pathway. Understanding how the IFN system is inhibited has provided critical insights into viral virulence and pathogenesis. Moreover, identification of factors encoded by viruses that modulate the JAK/STAT pathway has opened up opportunities to create new anti- viral drugs and rationally attenuated new generation vaccines, particularly for RNA viruses, by reverse genetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available