Journal
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Volume 3, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcdd3030025
Keywords
Ciona; cardiac development; cardiac cell specification; cardiac regeneration
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Funding
- National Institutes of Health [1R15HL104587-01]
- NIH/NHLBI [R01 HL108643]
- Transatlantic Networks of Excellence Program grant from the Leducq Foundation
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Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a basal Chordate, the Ciona model system presents a simple scaffold that recapitulates the basic blueprint of cardiac development in Chordates. Here we will focus on the development and cellular structure of the heart of the ascidian Ciona as compared to other Chordates, principally vertebrates. Comparison of the Ciona model system to heart development in other Chordates presents great potential for dissecting the genetic mechanisms that underlie congenital heart defects and disease at the cellular level and might provide additional insight into potential pathways for therapeutic cardiac regeneration.
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