Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 57, Issue 11, Pages 4847-4858Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.16-19890
Keywords
cone; optical coherence tomography; perimetry; rod
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Funding
- Chatlos Foundation
- National Eye Institute, National Institutes of Health [R24 EY 022012, P30 EY 001583]
- Foundation Fighting Blindness
- Research to Prevent Blindness
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PURPOSE. Previously, patients with RHO mutations and a class A phenotype were found to have severe early-onset loss of rod function, whereas patients with a class B phenotype retained rod function at least in certain retinal regions. Here class B patients were studied at different disease stages to understand the topographic details of the phenotype in preparation for therapies of this regionalized retinopathy. METHODS. A cohort of patients with RHO mutations and class B phenotype (n = 28; ages 1080 years) were studied with rod and cone perimetry and optical coherence tomography (OCT). RESULTS. At least three components of the phenotype were identified in these cross-sectional studies. Patients could have hemifield dysfunction, pericentral loss of function, or a diffuse rod sensitivity loss across the visual field. Combinations of these different patterns were also found. Colocalized photoreceptor layer thicknesses were in agreement with the psychophysical results. CONCLUSIONS. These disorders with regional retinal variation of severity require pre-evaluations before enrollment into clinical trials to seek answers to questions about where in the retina would be appropriate to deliver focal treatments, and, for retina-wide treatment strategies, where in the retina should be monitored for therapeutic efficacy (or safety).
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