Journal
BIOACTIVE MATERIALS
Volume 1, Issue 1, Pages 2-17Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2016.05.002
Keywords
Hernia repair; Hernia mesh; Hernia prosthesis; Hernia; Citric acid
Funding
- National Institutes of Health [EB012575, CA182670, HL118498]
- National Science Foundation (NSF) [DMR1313553, CMMI1266116, CMMI1537008]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1313553] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1537008] Funding Source: National Science Foundation
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Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multibillion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed. Commonly encountered complications and strategies to minimize these adverse effects are described, followed by a thorough description of the implant characteristics necessary for successful repair. Finally, available implants are categorized and their advantages and limitations are elucidated, including non-absorbable and absorbable (synthetic and biologically derived) prostheses, composite prostheses, and coated prostheses. This review not only summarizes the state of the art in hernia repair, but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods. (c) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license
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