Journal
ADVANCES IN MEDICAL SCIENCES
Volume 63, Issue 1, Pages 68-78Publisher
ELSEVIER URBAN & PARTNER SP Z O O
DOI: 10.1016/j.advms.2017.05.005
Keywords
Antioxidants; Non-enzymatic; Endogenous; Human
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The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a cascade of reactions and induces activation of multiple internal defence mechanisms (enzymatic or non-enzymatic) that provide removal of reactive species and their derivatives. The non-enzymatic antioxidants are represented by molecules characterized by the ability to rapidly inactivate radicals and oxidants. This paper focuses on the major intrinsic non-enzymatic antioxidants, including metal binding proteins (MBPs), glutathione (GSH), uric acid (UA), melatonin (MEL), bilirubin (BIL) and polyamines (PAs). (c) 2017 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.
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