Journal
EXPERIMENTAL DERMATOLOGY
Volume 25, Issue 1, Pages 62-63Publisher
WILEY
DOI: 10.1111/exd.12864
Keywords
aryl hydrocarbon receptor; mast cells; T cells
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Funding
- German Research Foundation [SFB938 TPK]
- ERC [233074]
- University Hospital Heidelberg
- Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS)
- Helmholtz International Graduate School for Cancer Research
- German Research Foundation (DFG)
- European Research Council (ERC) [233074] Funding Source: European Research Council (ERC)
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The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells (PECs) and lymph nodes, we studied in depth their phenotype in AhR-deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.
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