Journal
GLOBAL HEART
Volume 11, Issue 3, Pages 337-342Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.gheart.2016.07.005
Keywords
-
Categories
Funding
- National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC95162, N01-HC-95163, N01-HC-95164, N01-HC95165, N01-HC-95166, N01-HC-95167, N01-HC95168, N01-HC-95169]
- National Center for Research Resources [UL1-TR000040, UL1-TR001079]
Ask authors/readers for more resources
Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC > 0; above CAC > 400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available