Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 103, Issue 2, Pages 341-347Publisher
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.115.123281
Keywords
DASH diet; lipoproteins; saturated fat; triglyceride; blood pressure; dairy
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Funding
- Dairy Management Inc.
- National Center for Research Resources
- National Center for Advancing Translational Sciences, NIH through University of California, San Francisco Clinical & Translational Science Institute [UL1 RR024131]
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Background: The DASH (Dietary Approaches to Stop Hypertension) dietary pattern, which is high in fruit, vegetables, and low-fat dairy foods, significantly lowers blood pressure as well as low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol. Objective: The study was designed to test the effects of substituting full-fat for low-fat dairy foods in the DASH diet, with a corresponding increase in fat and a reduction in sugar intake, on blood pressure and plasma lipids and lipoproteins. Design: This was a 3-period randomized crossover trial in freeliving healthy individuals who consumed in random order a control diet, a standard DASH diet, and a higher-fat, lower-carbohydrate modification of the DASH diet (BF-DASH diet) for 3 wk each, separated by 2-wk washout periods. Laboratory measurements, which included lipoprotein particle concentrations determined by ion mobility, were made at the end of each experimental diet. Results: Thirty-six participants completed all 3 dietary periods. Blood pressure was reduced similarly with the DASH and HFDASH diets compared with the control diet. The HF-DASH diet significantly reduced triglycerides and large and medium very-low density lipoprotein (VLDL) particle concentrations and increased LDL peak particle diameter compared with the DASH diet. The DASH diet, but not the BF-DASH diet, significantly reduced LDL cholesterol, HDL cholesterol, apolipoprotein A-I, intermediate density lipoprotein and large LDL particles, and LDL peak diameter compared with the control diet. Conclusions: The BF-DASH diet lowered blood pressure to the same extent as the DASH diet but also reduced plasma triglyceride and VLDL concentrations without significantly increasing LDL cholesterol. This trial was registered at clinicaltrials.gov as NCT01404897.
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