Journal
ADVANCED MATERIALS
Volume 30, Issue 29, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201706706
Keywords
graded mineralization; interfacial tissue engineering; inverse opal scaffolds; mineral gradient; osteogenesis
Categories
Funding
- National Institutes of Health [R01 AR060820]
- Georgia Institute of Technology
Ask authors/readers for more resources
The design and fabrication of inverse opal scaffolds with gradations in mineral content to achieve spatial control of osteogenesis are described. The gradient in mineral content is established via the diffusion-limited transport of hydroxyapatite nanoparticles in a closely packed lattice of gelatin microbeads. The mineral-graded scaffold has an array of uniform pores and interconnected windows to facilitate efficient transport of nutrients and metabolic wastes, ensuring high cell viability. The graded distribution of mineral content can provide biochemical and mechanical cues for spatially regulating the osteogenic differentiation of adipose-derived stromal cells. This new class of scaffolds holds promise for engineering the interfaces between mineralized and unmineralized tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available