Related references
Note: Only part of the references are listed.Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
Jason B. Miller et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Injectable, Guest-Host Assembled Polyethylenimine Hydrogel for siRNA Delivery
Leo L. Wang et al.
BIOMACROMOLECULES (2017)
The pathology of the foreign body reaction against biomaterials
R. Klopfleisch et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)
Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype
Jenna L. Dziki et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Matthias A. Oberli et al.
NANO LETTERS (2017)
Bioresponsive materials
Yue Lu et al.
NATURE REVIEWS MATERIALS (2017)
Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms
Charles N. Serhan
FASEB JOURNAL (2017)
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
Tyrel T. Smith et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems
Christian Schneider et al.
JOURNAL OF CONTROLLED RELEASE (2017)
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Bian Wu et al.
JOURNAL OF VASCULAR SURGERY (2017)
Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
Siddharth Patel et al.
NANO LETTERS (2017)
Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
X. Luo et al.
NANOSCALE (2017)
Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery
Maria Mir et al.
NANOSCALE RESEARCH LETTERS (2017)
Spinal muscular atrophy approval boosts antisense drugs
Elie Dolgin
NATURE BIOTECHNOLOGY (2017)
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
Hao Yin et al.
NATURE BIOTECHNOLOGY (2017)
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
Joshua C. Doloff et al.
NATURE MATERIALS (2017)
Fabrication of fillable microparticles and other complex 3D microstructures
Kevin J. McHugh et al.
SCIENCE (2017)
Advances in engineering hydrogels
Yu Shrike Zhang et al.
SCIENCE (2017)
Advances in the delivery of RNA therapeutics: from concept to clinical reality
James C. Kaczmarek et al.
GENOME MEDICINE (2017)
Preparation and Characterization of Highly Aligned Carbon Nanotubes/Polyacrylonitrile Composite Nanofibers
Yanhua Song et al.
POLYMERS (2017)
CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic-co-glycolic acid)microparticles and films
Esther Y. Chen et al.
JOURNAL OF MATERIALS CHEMISTRY B (2017)
Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery
Maria Mir et al.
NANOSCALE RESEARCH LETTERS (2017)
Tools for translation: non-viral materials for therapeutic mRNA delivery
Khalid A. Hajj et al.
NATURE REVIEWS MATERIALS (2017)
Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites
Jessica D. Weaver et al.
SCIENCE ADVANCES (2017)
Evolution of macromolecular complexity in drug delivery systems
Ashok Kakkar et al.
NATURE REVIEWS CHEMISTRY (2017)
Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications
Kevin T. Campbell et al.
PLOS ONE (2017)
Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers
Yunfeng Yan et al.
BIOMACROMOLECULES (2017)
Next-Generation Chimeric Antigen Receptor T-Cell Therapy: Going off the Shelf
Marco Ruella et al.
BIODRUGS (2017)
Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir
Muneeb Mohideen et al.
BIOMATERIALS (2017)
Engineering and physical sciences in oncology: challenges and opportunities
Michael J. Mitchell et al.
NATURE REVIEWS CANCER (2017)
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
Owen S. Fenton et al.
ADVANCED MATERIALS (2017)
Controlled release of basic fibroblast growth factor for angiogenesis using acoustically-responsive scaffolds
Alexander Moncion et al.
BIOMATERIALS (2017)
Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo
Xinfu Zhang et al.
ACS APPLIED MATERIALS & INTERFACES (2017)
Precise manipulation of biophysical particle parameters enables control of proinflammatory cytokine production in presence of TLR 3 and 4 ligands
Yoshinori Kakizawa et al.
ACTA BIOMATERIALIA (2017)
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Javier O. Morales et al.
AAPS JOURNAL (2017)
Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling
Mary Caitlin P. Sok et al.
ACTA BIOMATERIALIA (2017)
Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors
Yiran Zheng et al.
ACS NANO (2017)
The Principles of Engineering Immune Cells to Treat Cancer
Wendell A. Lim et al.
CELL (2017)
Biomimetic biodegradable artificial antigen presenting with PD-1 blockade to treat melanoma cells synergize
A. K. Kosmides et al.
BIOMATERIALS (2017)
Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells
R. Brad Jones et al.
BIOMATERIALS (2017)
Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
Joao Conde et al.
NATURE MATERIALS (2016)
Switching the Immunogenicity of Peptide Assemblies Using Surface Properties
Yi Wen et al.
ACS NANO (2016)
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
Owen S. Fenton et al.
ADVANCED MATERIALS (2016)
Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
James C. Kaczmarek et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Effects of Chemically Modified Messenger RNA on Protein Expression
Bin Li et al.
BIOCONJUGATE CHEMISTRY (2016)
Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Manju Kanamala et al.
BIOMATERIALS (2016)
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
Kevin J. Kauffman et al.
BIOMATERIALS (2016)
Alginate/magnetite hybrid beads for magnetically stimulated release of dopamine
Stalin Kondaveeti et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2016)
Therapeutic RNAi robed with ionic liquid moieties as a simple, scalable prodrug platform for treating skin disease
Michael Zakrewsky et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Materials for non-viral intracellular delivery of messenger RNA therapeutics
Kevin J. Kauffman et al.
JOURNAL OF CONTROLLED RELEASE (2016)
Emerging Frontiers in Drug Delivery
Mark W. Tibbitt et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
Lena M. Kranz et al.
NATURE (2016)
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Arturo J. Vegas et al.
NATURE BIOTECHNOLOGY (2016)
Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
Hao Yin et al.
NATURE BIOTECHNOLOGY (2016)
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice
Arturo J. Vegas et al.
NATURE MEDICINE (2016)
A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy
Peng Mi et al.
Nature Nanotechnology (2016)
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Daniel Bobo et al.
PHARMACEUTICAL RESEARCH (2016)
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Hok Hei Tam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
Jasdave S. Chahal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals
Andrew M. Bellinger et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys
Rosie Z. Yu et al.
NUCLEIC ACID THERAPEUTICS (2016)
Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific
Lisa H. Tostanoski et al.
CELL REPORTS (2016)
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
Luo Gu et al.
NATURE REVIEWS CANCER (2016)
Thermogelling bioadhesive scaffolds for intervertebral disk tissue engineering: Preliminary in vitro comparison of aldehyde-based versus alginate microparticle-mediated adhesion
C. Wiltsey et al.
ACTA BIOMATERIALIA (2015)
Biomaterial Strategies for Immunomodulation
Nathan A. Hotaling et al.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 17 (2015)
Genipin-crosslinked catechol-chitosan mucoadhesive hydrogels for buccal drug delivery
Jinke Xu et al.
BIOMATERIALS (2015)
Magnetic/pH-responsive beads based on caboxymethyl chitosan and κ-carrageenan and controlled drug release
Gholam Reza Mandavinia et al.
CARBOHYDRATE POLYMERS (2015)
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Xiao Wang et al.
CELL (2015)
Light-responsive azobenzene-based glycopolymer micelles for targeted drug delivery to melanoma cells
Samuel Pearson et al.
EUROPEAN POLYMER JOURNAL (2015)
Controlled Drug Delivery: Historical perspective for the next generation
Yeon Hee Yun et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Shape and size-dependent immune response to antigen-carrying nanoparticles
Sunny Kumar et al.
JOURNAL OF CONTROLLED RELEASE (2015)
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
Kevin J. Kauffman et al.
NANO LETTERS (2015)
Selenium/tellurium containing polymer materials in nanobiotechnology
Wei Cao et al.
NANO TODAY (2015)
Control of adaptive immunity by the innate immune system
Akiko Iwasaki et al.
NATURE IMMUNOLOGY (2015)
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Shiyi Zhang et al.
NATURE MATERIALS (2015)
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh et al.
NATURE MATERIALS (2015)
Knocking down disease: a progress report on siRNA therapeutics
Anders Wittrup et al.
NATURE REVIEWS GENETICS (2015)
The effect of RNA base lesions on mRNA translation
Alessandro Calabretta et al.
NUCLEIC ACIDS RESEARCH (2015)
Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs
Q. Fu et al.
POLYMER CHEMISTRY (2015)
Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
Jicheng Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown
Pratik S. Randeria et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Charles N. Serhan et al.
SEMINARS IN IMMUNOLOGY (2015)
Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications
Arijit Gandhi et al.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies
Saar Gill et al.
IMMUNOLOGICAL REVIEWS (2015)
Biopolymer implants enhance the efficacy of adoptive T-cell therapy
Sirkka B. Stephan et al.
NATURE BIOTECHNOLOGY (2015)
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
Jaeyun Kim et al.
NATURE BIOTECHNOLOGY (2015)
Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials
Ted T. Lee et al.
NATURE MATERIALS (2015)
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance
Roberto A. Maldonado et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Lipid Mediators in the Resolution of Inflammation
Charles N. Serhan et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Nanodiamond-embedded contact lenses for glaucoma treatment: a different sort of twinkle in your eye?
James Potticary
THERAPEUTIC DELIVERY (2014)
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
Nicolas Bertrand et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
Molecule Drugs for Enhanced Therapeutic Efficacy
Tianyue Jiang et al.
ADVANCED FUNCTIONAL MATERIALS (2014)
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Nasim Annabi et al.
ADVANCED MATERIALS (2014)
Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo
Omar F. Khan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Tissue engineering of electrically responsive tissues using polyaniline based polymers: A review
Taimoor H. Qazi et al.
BIOMATERIALS (2014)
Particle shape dependence of CD8+T cell activation by artificial antigen presenting cells
Joel C. Sunshine et al.
BIOMATERIALS (2014)
Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging
Fei Ye et al.
BIOMATERIALS (2014)
Chitosan/glucose 1-phosphate as new stable in situ forming depot system for controlled drug delivery
Stephanie Supper et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)
In situ covalently cross-linked PEG hydrogel for ocular drug delivery applications
Jing Yu et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)
An overview of clinical and commercial impact of drug delivery systems
Aaron C. Anselmo et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Single compartment drug delivery
Michael J. Cima et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Controlled drug delivery systems: Past forward and future back
Kinam Park
JOURNAL OF CONTROLLED RELEASE (2014)
Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
Wujin Sun et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages
Diane C. Forbes et al.
MACROMOLECULAR BIOSCIENCE (2014)
Smart pH- and reduction-dual-responsive folate-PEG-coated polymeric lipid vesicles for tumor-triggered targeted drug delivery
Sheng Wang et al.
NANOSCALE (2014)
Structure-based programming of lymph-node targeting in molecular vaccines
Haipeng Liu et al.
NATURE (2014)
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman et al.
NATURE NANOTECHNOLOGY (2014)
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
Samir Mitragotri et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
mRNA-based therapeutics - developing a new class of drugs
Ugur Sahin et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Engineering adeno-associated viruses for clinical gene therapy
Melissa A. Kotterman et al.
NATURE REVIEWS GENETICS (2014)
Non-viral vectors for gene-based therapy
Hao Yin et al.
NATURE REVIEWS GENETICS (2014)
Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy
Nathaniel Huebsch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Near-infrared-actuated devices for remotely controlled drug delivery
Brian P. Timko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft
Thusitha Gajanayake et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Kathryn A. Whitehead et al.
NATURE COMMUNICATIONS (2014)
Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors: Current Progress and Overview
Hao-Li Liu et al.
THERANOSTICS (2014)
Silver Nanoparticles Impregnated Alginate-Chitosan-Blended Nanocarrier Induces Apoptosis in Human Glioblastoma Cells
Shilpa Sharma et al.
ADVANCED HEALTHCARE MATERIALS (2014)
Smart polymers for the controlled delivery of drugs - a concise overview
Honey Priya James et al.
ACTA PHARMACEUTICA SINICA B (2014)
Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release
Ho-Joong Kim et al.
ACS NANO (2014)
Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo
Kenichi Niikura et al.
ACS NANO (2013)
Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery
Zhen Gu et al.
ACS NANO (2013)
Liposomal drug delivery systems: From concept to clinical applications
Theresa M. Allen et al.
ADVANCED DRUG DELIVERY REVIEWS (2013)
A Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells
Min Suk Shim et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Eteplirsen for the Treatment of Duchenne Muscular Dystrophy
Jerry R. Mendell et al.
ANNALS OF NEUROLOGY (2013)
Clinical Application of Drug Delivery Systems in Cancer Chemotherapy: Review of the Efficacy and Side Effects of Approved Drugs
Takuya Iwamoto
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)
pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors
Ching-Yi Chen et al.
BIOMATERIALS (2013)
Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery
Ru Cheng et al.
BIOMATERIALS (2013)
Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine
Jeffrey A. Silverman et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2013)
New directions in thermoresponsive polymers
Debashish Roy et al.
CHEMICAL SOCIETY REVIEWS (2013)
Temperature- and light-responsive smart polymer materials
Florian D. Jochum et al.
CHEMICAL SOCIETY REVIEWS (2013)
A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics
Stephanie D. Steichen et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances
Zia Ur Rehman et al.
JOURNAL OF CONTROLLED RELEASE (2013)
CANCER VACCINES Material breach
Elie Dolgin
NATURE (2013)
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
Gaurav Sahay et al.
NATURE BIOTECHNOLOGY (2013)
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Lei Zhang et al.
NATURE BIOTECHNOLOGY (2013)
Stimuli-responsive nanocarriers for drug delivery
Simona Mura et al.
NATURE MATERIALS (2013)
Engineering synthetic vaccines using cues from natural immunity
Darrell J. Irvine et al.
NATURE MATERIALS (2013)
Delivery materials for siRNA therapeutics
Rosemary Kanasty et al.
NATURE MATERIALS (2013)
Nitroxide-mediated polymerization
Julien Nicolas et al.
PROGRESS IN POLYMER SCIENCE (2013)
Minimal Self Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
Pia L. Rodriguez et al.
SCIENCE (2013)
Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
Samuel A. Jensen et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Photo-Responsive Shape-Memory and Shape-Changing Liquid-Crystal Polymer Networks
Danish Iqbal et al.
MATERIALS (2013)
Ultrasound and pH Dually Responsive Polymer Vesicles for Anticancer Drug Delivery
Wenqin Chen et al.
SCIENTIFIC REPORTS (2013)
Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation
Minglin Ma et al.
ADVANCED HEALTHCARE MATERIALS (2013)
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
Barbara L. Mui et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2013)
Nucleic Acid Delivery: The Missing Pieces of the Puzzle?
Juliane Nguyen et al.
ACCOUNTS OF CHEMICAL RESEARCH (2012)
Drug Release from Electric-Field-Responsive Nanoparticles
Jun Ge et al.
ACS NANO (2012)
Nanoparticle and targeted systems for cancer therapy
Lisa Brannon-Peppas et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
Laura M. Ensign et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Nanoparticles in cancer therapy and diagnosis
Irene Brigger et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Enzyme-responsive nanoparticles for drug release and diagnostics
Roberto de la Rica et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Regulatory T Cells: Mechanisms of Differentiation and Function
Steven Z. Josefowicz et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles
Matthias T. Stephan et al.
BIOMATERIALS (2012)
Magnetite-loaded fluorine-containing polymeric micelles for magnetic resonance imaging and drug delivery
Xiaolong Li et al.
BIOMATERIALS (2012)
Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts
James D. Bryers et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Jinming Hu et al.
CHEMICAL SOCIETY REVIEWS (2012)
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Nazila Kamaly et al.
CHEMICAL SOCIETY REVIEWS (2012)
Stimuli-responsive supramolecular polymeric materials
Xuzhou Yan et al.
CHEMICAL SOCIETY REVIEWS (2012)
Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing
Glen F. Deleavey et al.
CHEMISTRY & BIOLOGY (2012)
Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice
Jianfeng Guo et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Crucial factors and emerging concepts in ultrasound-triggered drug delivery
Bart Geers et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Oral delivery of small RNA and DNA
Diane C. Forbes et al.
JOURNAL OF CONTROLLED RELEASE (2012)
Doxil® - The first FDA-approved nano-drug: Lessons learned
Yechezkel (Chezy) Barenholz
JOURNAL OF CONTROLLED RELEASE (2012)
A facile preparation of targetable pH-sensitive polymeric nanocarriers with encapsulated magnetic nanoparticles for controlled drug release
Shun Yang et al.
JOURNAL OF MATERIALS CHEMISTRY (2012)
Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
Rong Tong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin
Katalin Kariko et al.
MOLECULAR THERAPY (2012)
Atom Transfer Radical Polymerization (ATRP): Current Status and Future Perspectives
Krzysztof Matyjaszewski
MACROMOLECULES (2012)
Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation
Dan Zheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
ATRP in the design of functional materials for biomedical applications
Daniel J. Siegwart et al.
PROGRESS IN POLYMER SCIENCE (2012)
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Zhiliang Cheng et al.
SCIENCE (2012)
Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
John Scholler et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip
Robert Farra et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Shear-thinning hydrogels for biomedical applications
Murat Guvendiren et al.
SOFT MATTER (2012)
Endoprotease-Mediated Intracellular Protein Delivery Using Nanocapsules
Anuradha Biswas et al.
ACS NANO (2011)
Ceramic materials in dentistry: historical evolution and current practice
J. R. Kelly et al.
AUSTRALIAN DENTAL JOURNAL (2011)
Redox-responsive nanocapsules for intracellular protein delivery
Muxun Zhao et al.
BIOMATERIALS (2011)
A Discussion of the pH-Dependent Protonation Behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))
Hoyoung Lee et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Biomedical Applications of Biodegradable Polymers
Bret D. Ulery et al.
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (2011)
Photochemically and Electrochemically Triggered Au Nanoparticles Sponges
Dora Balogh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics
Kyle E. Broaders et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Michael S. D. Kormann et al.
NATURE BIOTECHNOLOGY (2011)
Exploring the Genomes of Cancer Cells: Progress and Promise
Michael R. Stratton
SCIENCE (2011)
Biocompatibility of implants: lymphocyte/macrophage interactions
James M. Anderson et al.
SEMINARS IN IMMUNOPATHOLOGY (2011)
Silencing or Stimulation? siRNA Delivery and the Immune System
Kathryn A. Whitehead et al.
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2 (2011)
Remotely Triggerable Drug Delivery Systems
Brian P. Timko et al.
ADVANCED MATERIALS (2010)
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
Dan R. Littman et al.
CELL (2010)
Monodisperse alginate microcapsules with oil core generated from a microfluidic device
Ping-Wei Ren et al.
JOURNAL OF COLLOID AND INTERFACE SCIENCE (2010)
mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers
Joanna Rejman et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Electrochemically controlled drug delivery based on intrinsically conducting polymers
Darren Svirskis et al.
JOURNAL OF CONTROLLED RELEASE (2010)
Lipid-based nanotherapeutics for siRNA delivery
A. Schroeder et al.
JOURNAL OF INTERNAL MEDICINE (2010)
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
Frederick J. Raal et al.
LANCET (2010)
Rational design of cationic lipids for siRNA delivery
Sean C. Semple et al.
NATURE BIOTECHNOLOGY (2010)
Emerging applications of stimuli-responsive polymer materials
Martien A. Cohen Stuart et al.
NATURE MATERIALS (2010)
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles
Matthias T. Stephan et al.
NATURE MEDICINE (2010)
Lipid-like materials for low-dose, in vivo gene silencing
Kevin T. Love et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct
Brian C. Schanen et al.
ACS NANO (2009)
Impact of Nanotechnology on Drug Delivery
Omid C. Farokhzad et al.
ACS NANO (2009)
Synthesis of Functional Polymers by Post-Polymerization Modification
Marc A. Gauthier et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties
Lars Linderoth et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
The Inflammasomes: Guardians of the Body
Fablo Martinon et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
Cell-controlled and spatially arrayed gene delivery from fibrin hydrogels
Pedro Lei et al.
BIOMATERIALS (2009)
Reduction-sensitive polymers and bioconjugates for biomedical applications
Fenghua Meng et al.
BIOMATERIALS (2009)
Bioapplications of RAFT Polymerization
Cyrille Boyer et al.
CHEMICAL REVIEWS (2009)
Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
Shomyseh Sanjabi et al.
CURRENT OPINION IN PHARMACOLOGY (2009)
Oral osmotically driven systems: 30 years of development and clinical use
Vincent Malaterre et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2009)
Expansile Nanoparticles: Synthesis, Characterization, and in Vivo Efficacy of an Acid-Responsive Polymeric Drug Delivery System
Aaron P. Griset et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Antibody-Mediated Targeting of siRNA via the Human Insulin Receptor Using Avidin-Biotin Technology
Chun-Fang Xia et al.
MOLECULAR PHARMACEUTICS (2009)
A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery
James J. Lu et al.
MOLECULAR PHARMACEUTICS (2009)
Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network
Zhen Gu et al.
NANO LETTERS (2009)
A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery
Todd Hoare et al.
NANO LETTERS (2009)
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Matthew Spite et al.
NATURE (2009)
Materials engineering for immunomodulation
Jeffrey A. Hubbell et al.
NATURE (2009)
Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function
Daniel T. Simon et al.
NATURE MATERIALS (2009)
Infection-mimicking materials to program dendritic cells in situ
Omar A. Ali et al.
NATURE MATERIALS (2009)
Knocking down barriers: advances in siRNA delivery
Kathryn A. Whitehead et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
Jesper B. Bramsen et al.
NUCLEIC ACIDS RESEARCH (2009)
PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine
Chien-Chi Lin et al.
PHARMACEUTICAL RESEARCH (2009)
Formulation and Pharmacokinetics of Self-Assembled Rifampicin Nanoparticle Systems for Pulmonary Delivery
Jean C. Sung et al.
PHARMACEUTICAL RESEARCH (2009)
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
Fiona A. Sharp et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
April M. Kloxin et al.
SCIENCE (2009)
In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice
Omar A. Ali et al.
SCIENCE TRANSLATIONAL MEDICINE (2009)
Systems medicine: the future of medical genomics and healthcare
Charles Auffray et al.
GENOME MEDICINE (2009)
Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: A 10-year institutional experience
Frank J. Attenello et al.
ANNALS OF SURGICAL ONCOLOGY (2008)
Dissolving microneedles for transdermal drug delivery
Jeong W. Lee et al.
BIOMATERIALS (2008)
On the mechanisms of biocompatibility
David F. Williams
BIOMATERIALS (2008)
Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice
Esther Merki et al.
CIRCULATION (2008)
The origins and evolution of controlled drug delivery systems
Allan S. Hoffman
JOURNAL OF CONTROLLED RELEASE (2008)
Efficient in vivo delivery of siRNA to the liver by conjugation of α-tocopherol
Kazutaka Nishina et al.
MOLECULAR THERAPY (2008)
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Stephanie C. Eisenbarth et al.
NATURE (2008)
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc et al.
NATURE BIOTECHNOLOGY (2008)
Transdermal drug delivery
Mark R. Prausnitz et al.
NATURE BIOTECHNOLOGY (2008)
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Veit Hornung et al.
NATURE IMMUNOLOGY (2008)
Hydrogels in drug delivery: Progress and challenges
Todd R. Hoare et al.
POLYMER (2008)
Foreign body reaction to biomaterials
James M. Anderson et al.
SEMINARS IN IMMUNOLOGY (2008)
The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
Gregory L. Verdine et al.
CLINICAL CANCER RESEARCH (2007)
Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs
Simona Gallorini et al.
JOURNAL OF IMMUNOLOGY (2007)
Nanocarriers as an emerging platform for cancer therapy
Dan Peer et al.
NATURE NANOTECHNOLOGY (2007)
Wear particles, periprosthetic osteolysis and the immune system
Stuart B. Goodman
BIOMATERIALS (2007)
Remotely triggered release from magnetic nanoparticles
Austin M. Derfus et al.
ADVANCED MATERIALS (2007)
Current ceramic materials and systems with clinical recommendations: A systematic review
Heather J. Conrad et al.
JOURNAL OF PROSTHETIC DENTISTRY (2007)
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
Sterghios Athanasios Moschos et al.
BIOCONJUGATE CHEMISTRY (2007)
Magnetic nanoparticles for drug delivery
Manuel Arruebo et al.
NANO TODAY (2007)
Biocompatibility of polypyrrole particles: an in-vivo study in mice
Almira Ramanaviciene et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2007)
Living ring-opening metathesis polymerization
Christopher W. Bielawski et al.
PROGRESS IN POLYMER SCIENCE (2007)
Inhaling medicines: delivering drugs to the body through the lungs
John S. Patton et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Lipid-based nanoparticles for nucleic acid delivery
Weijun Li et al.
PHARMACEUTICAL RESEARCH (2007)
Thermo- and pH-responsive polymers in drug delivery
Dirk Schmaljohann
ADVANCED DRUG DELIVERY REVIEWS (2006)
RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system
Kenneth A. Howard et al.
MOLECULAR THERAPY (2006)
Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications
Moon Suk Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Hydrogels in biology and medicine: From molecular principles to bionanotechnology
Nicholas A. Peppas et al.
ADVANCED MATERIALS (2006)
Oligonucleotide-modified gold nanoparticles for intracellular gene regulation
NL Rosi et al.
SCIENCE (2006)
Electrically controlled drug delivery from biotin-doped conductive polypyrrole
PM George et al.
ADVANCED MATERIALS (2006)
Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode
R Wadhwa et al.
JOURNAL OF CONTROLLED RELEASE (2006)
Conducting-polymer nanotubes for controlled drug release
MR Abidian et al.
ADVANCED MATERIALS (2006)
Enzyme-responsive materials: a new class of smart biomaterials
Rein V. Ulijn
JOURNAL OF MATERIALS CHEMISTRY (2006)
High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation
YB Zhao et al.
MOLECULAR THERAPY (2006)
The SIRP family of receptors and immune regulation
AN Barclay et al.
NATURE REVIEWS IMMUNOLOGY (2006)
Differential levels of dendritic cell maturation on different biomaterials used in combination products
JE Babensee et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2005)
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
DV Morrissey et al.
NATURE BIOTECHNOLOGY (2005)
Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA
K Karikó et al.
IMMUNITY (2005)
Positional effect of chemical modifications on short interference RNA activity in mammalian cells
TP Prakash et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
JH Park et al.
JOURNAL OF CONTROLLED RELEASE (2005)
Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency
IS Zuhorn et al.
MOLECULAR THERAPY (2005)
Physical methods for gene transfer: Improving the kinetics of gene delivery into cells
S Mehier-Humbert et al.
ADVANCED DRUG DELIVERY REVIEWS (2005)
Relaxational behavior and swelling-pH master curves of poly[(diethylaminoethyl methacrylate)-graft-(ethylene glycol)] hydrogels
K Podual et al.
POLYMER INTERNATIONAL (2005)
Innovation - Healing sound: the use of ultrasound in drug delivery and other therapeutic applications
S Mitragotri
NATURE REVIEWS DRUG DISCOVERY (2005)
Cancer nanotechnology: Opportunities and challenges
M Ferrari
NATURE REVIEWS CANCER (2005)
Stimuli responsive polymers for biomedical applications
CDH Alarcón et al.
CHEMICAL SOCIETY REVIEWS (2005)
Recent advances with liposomes as pharmaceutical carriers
VP Torchilin
NATURE REVIEWS DRUG DISCOVERY (2005)
Drug delivery systems: Entering the mainstream
TM Allen et al.
SCIENCE (2004)
Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression
K Miyata et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Glutathione metabolism and its implications for health
GY Wu et al.
JOURNAL OF NUTRITION (2004)
Oxidation-responsive polymeric vesicles
A Napoli et al.
NATURE MATERIALS (2004)
Current status and future potential of transdermal drug delivery
MR Prausnitz et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma
A Giese et al.
JOURNAL OF NEURO-ONCOLOGY (2004)
Controlled structure and properties of thermoresponsive nanoparticle-hydrogel composites
C Wang et al.
ADVANCED MATERIALS (2004)
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
J Soutschek et al.
NATURE (2004)
Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
C Lorenz et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Stimuli-responsive conjugated copolymers having electro-active azulene and bithiophene units in the polymer skeleton: Effect of protonation and p-doping on conducting properties
FK Wang et al.
MACROMOLECULES (2004)
Smart and genetically engineered biomaterials and drug delivery systems
J Kopecek
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2003)
siRNA function in RNAi: A chemical modification analysis
YL Chiu et al.
RNA (2003)
Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
JL Bourges et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)
Advances in biomaterials, drug delivery, and bionanotechnology
R Langer et al.
AICHE JOURNAL (2003)
Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery
DG Anderson et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Nasal drug delivery: new developments and strategies
L Illum
DRUG DISCOVERY TODAY (2002)
Targeted drug delivery by thermally responsive polymers
A Chilkoti et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Reducing capsular thickness and enhancing angiogenesis around implant drug release systems
BD Ratner
JOURNAL OF CONTROLLED RELEASE (2002)
Recent metallic materials for biomedical applications
M Niinomi
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE (2002)
Pharmacokinetics of the carmustine implant
AB Fleming et al.
CLINICAL PHARMACOKINETICS (2002)
Fomivirsen - Clinical pharmacology and potential drug interactions
RS Geary et al.
CLINICAL PHARMACOKINETICS (2002)
Toll-like receptors and innate immunity
R Medzhitov
NATURE REVIEWS IMMUNOLOGY (2001)
Design and synthesis of stimuli-responsive conjugated polymers having azobenzene units in the main chain
A Izumi et al.
MACROMOLECULES (2001)
'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG):: influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
R Gref et al.
COLLOIDS AND SURFACES B-BIOINTERFACES (2000)
Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts
K Podual et al.
JOURNAL OF CONTROLLED RELEASE (2000)
Preparation and dynamic response of cationic copolymer hydrogels containing glucose oxidase
K Podual et al.
POLYMER (2000)
Biomaterials in drug delivery and tissue engineering: One laboratory's experience
R Langer
ACCOUNTS OF CHEMICAL RESEARCH (2000)