Journal
ADVANCED MATERIALS
Volume 30, Issue 28, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201801527
Keywords
checkpoint blockade; drug delivery; hydrogel; immunotherapy; stimuli responsive
Categories
Funding
- UNC/NC State Startup Grant
- UNC/NC Sloan Research Fellowship
- National Natural Science Foundation of China [NSFC 51773199, 51622307, 51390484]
- Scientific Development Program of Jilin Province [20170520126JH]
Ask authors/readers for more resources
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response of patient rate as well as systemic side effects. Here, a combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species (ROS)-responsive polypeptide gel for sustained release of anti-programmed cell death-ligand 1 antibody and dextro-1-methyl tryptophan, inhibitor of indoleamine-2,3-dioxygenase with leveraging the ROS level in the tumor microenvironment. This bioresponsive gel depot can effectively reduce the local ROS level and facilitate release of immunotherapeutics, which leads to enhanced anti-melanoma efficacy in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available