Journal
ADVANCED MATERIALS
Volume 30, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201706887
Keywords
enzyme mimicking; flexible electrochemical sensors; guanosine; low-molecular-weight hydrogels; self-assembly
Categories
Funding
- Jane and Aatos Erkko Foundation [4704010]
- STCSM [17JC1400200]
- Shanghai Pujiang Talent Project [16PJ1402700, 15PJ1401800]
- National Science Foundation of China [21722502, 21705048, 51763019, 21505045]
- China Postdoctoral Science Foundation [2017T100283, 2015M581565]
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Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as ink to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)(4) with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.
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