Journal
ADVANCED MATERIALS
Volume 30, Issue 34, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201802440
Keywords
DNA strand displacement; DNA tweezers; electrical wireless biosensor; graphene FET biosensor; single nucleotide polymorphism (SNP) detection
Categories
Funding
- National Institute on Drug Abuse [R01DA024871]
- National Institute on Aging [R01AG028709]
- Department of Mechanical and Aerospace Engineering, UCSD
- National Institute of Environmental Health Sciences, NIH [1P30 ES013508]
- National Key R&D Program of China [2016YFA0201200, 2016YFA0400900]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES013508] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG028709] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA024871] Funding Source: NIH RePORTER
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Electronic DNA-biosensor with a single nucleotide resolution capability is highly desirable for personalized medicine. However, existing DNA-biosensors, especially single nucleotide polymorphism (SNP) detection systems, have poor sensitivity and specificity and lack real-time wireless data transmission. DNA-tweezers with graphene field effect transistor (FET) are used for SNP detection and data are transmitted wirelessly for analysis. Picomolar sensitivity of quantitative SNP detection is achieved by observing changes in Dirac point shift and resistance change. The use of DNA-tweezers probe with high-quality graphene FET significantly improves analytical characteristics of SNP detection by enhancing the sensitivity more than 1000-fold in comparison to previous work. The electrical signal resulting from resistance changes triggered by DNA strand-displacement and related changes in the DNA geometry is recorded and transmitted remotely to personal electronics. Practical implementation of this enabling technology will provide cheaper, faster, and portable point-of-care molecular health status monitoring and diagnostic devices.
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