Journal
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnint.2016.00026
Keywords
connexin hemichannels; Cx hemichannels; connexin 43; pannexin; astrocytes; memory
Categories
Funding
- CAEN from the ISFN
- CONICYT [ACT 1104, ACT 1411]
- [FONDECYT 11121133]
- [1160710]
- [1120214]
- [1160986]
- [UNAB DI-603-14/N]
- [CORFO 14IDL2-30195]
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Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.
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