Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 36, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201803804
Keywords
bioimaging; chemo-photodynamic therapy; mesoporous MnO2; tumor microenvironments; upconversion
Categories
Funding
- National Natural Science Foundation of China [NSFC 51772059, 51472058, 51602072, 51720105015, 51332008, 51575528]
- China Postdoctoral Science Foundation [2015M581430, 2016T90269]
- Natural Science Foundation of Heilongjiang Province [B2015020]
- Harbin Sci.-Tech. Innovation Foundation [2016RAXXJ005]
- PhD Student Research and Innovation Fund of the Fundamental Research Funds for the Central Universities [HEUGIP201713]
- projects for science and technology development plan of Jilin province [20170414003GH, 20160101300JC]
- Fundamental Research funds for the Central Universities
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The insufficient blood flow and oxygen supply in solid tumor cause hypoxia, which leads to low sensitivity of tumorous cells and thus causing poor treatment outcome. Here, mesoporous manganese dioxide (mMnO(2)) with ultrasensitive biodegradability in a tumor microenvironment (TME) is grown on upconversion photodynamic nanoparticles for not only TME-enhanced bioimaging and drug release, but also for relieving tumor hypoxia, thereby markedly improving photodynamic therapy (PDT). In this nanoplatform, mesoporous silica coated upconversion nanoparticles (UCNPs@mSiO(2)) with covalently loaded chlorin e6 are obtained as near-infrared light mediated PDT agents, and then a mMnO(2) shell is grown via a facile ultrasonic way. Because of its unique mesoporous structure, the obtained nanoplatform postmodified with polyethylene glycol can load the chemotherapeutic drug of doxorubicin (DOX). When used for antitumor application, the mMnO(2) degrades rapidly within the TME, releasing Mn2+ ions, which couple with trimodal (upconversion luminescence, computed tomography (CT), and magnetic resonance imaging) imaging of UCNPs to perform a self-enhanced imaging. Significantly, the degradation of mMnO(2) shell brings an efficient DOX release, and relieve tumor hypoxia by simultaneously inducing decomposition of tumor endogenous H2O2 and reduction of glutathione, thus achieving a highly potent chemo-photodynamic therapy.
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