Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 240, Issue 11, Pages 1513-1519Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370215573394
Keywords
Cisplatin; apoptosis; endoplasmic reticulum stress; epigallocatechin-3-gallate; nephrotoxicity
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Funding
- National Key Technology Support Program [2011BAI10B01]
- National Natural Science Foundation of China [81200529]
- Natural Science Foundation of Shandong Province [ZR2012HQ001]
- Shandong Postdoctoral Sustentation Fund [10000072312055]
- Independent Innovation Foundation of Shandong University (IIFSDU) [2012TS204, 2012ST167]
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Cisplatin (CP)-induced nephrotoxicity hampers its application in clinic. Green tea, particularly its predominant polyphenolic constituent epigallocatechin-3-gallate (EGCG), possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. The present study was designed to investigate the protective effects of EGCG against CP-induced nephrotoxicity in mice. Male C57/BL6 mice in different groups received single injection of CP (20mg/kg) and EGCG (100mg/kg) in various sets and kidney tissues and blood were collected after killing. Then, samples were used for biochemical and immunohistochemical assay. Our results showed EGCG decreased biochemical factors and immunohistochemical damage induced by CP. Besides, expression of phosphorylated-extracellular signal-regulated kinase (p-ERK), glucose-regulated protein 78 (GRP78), caspase-12, and apoptosis of kidney were decreased by EGCG via inhibition of endoplasmic reticulum (ER) stress-induced apoptosis.
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