Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201801355
Keywords
autoimmune diseases; cell membrane; macrophages; nanoparticles; porous silicon
Categories
Funding
- University of Helsinki Research Funds
- Sigrid Juselius Foundation [4704580]
- HiLIFE Research Funds
- European Research Council under the European Union's Seventh Framework Programme (FP) [310892]
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Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles' surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.
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