Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201800310
Keywords
Fe3O4@Au; multimodal imaging; phototheranostics; photothermal therapy; supraparticles
Categories
Funding
- National Natural Science Foundation of China [21771090, 21673104, 21471068, 21631005, 21522102, 51602029, 21503095, 31771084]
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Nanomaterials with high biocompatibility and efficient photothermal conversion have drawn tremendous attention for tumor diagnosis and treatment. In this study, spiky Fe3O4@Au supraparticles (SPs) are used as phototherapy and multimodal imaging agents. The SPs show excellent photothermal and photodynamic therapeutic effects, with a photothermal conversion efficiency of 31%, and allow tumor-targeted imaging, including computed tomographic, photoacoustic, and magnetic resonance imaging. The SPs show excellent biocompatibility both in vitro and in vivo. Furthermore, because of their remarkable absorption at near-infrared region, the SPs obliterate a tumor under 808 nm irradiation. With their capacity for highly integrated multimodal imaging and multiple therapeutic functions, SPs are a promising agent for application to clinical practice.
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