Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 28, Issue 14, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201706709
Keywords
anti-infective coating; photodynamic therapy; quaternary ammonium; synergistic antibacterials
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Funding
- National Key Research and Development Program of China [2016YFC1100404]
- National Natural Science Foundation of China [51733001, 51503012]
- Beijing Natural Science Foundation [7161001]
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Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug-resistant bacteria. In this work, eosin Y (EY)-based antibacterial polycations (EY-QEGED-R, R = -CH3 or -C6H13) with versatile types of functional components including quaternary ammonium, photosensitizer, primary amine, and hydroxyl species are readily synthesized based on simple ring-opening reactions. In the presence of light irradiation, such antibacterial polymers exhibit high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus. In particular, EY-QEGED-R elicits a remarkable synergistic antibacterial activity owing to the combined photodynamic and quaternary ammonium antibacterial effects. Due to its rich primary amine groups, EY-QEGED-R also can be readily coated on different substrates, such as glass slides and nonwoven fabrics via an adhesive layer of polydopamine. The resultant surface coating of EY-QEGED-CH3 (s-EY-QEGED-CH3) produces excellent in vitro antibacterial efficacy. The plentiful hydroxyl groups impart s-EY-QEGED-CH3 with potential antifouling capability against dead bacteria. The antibacterial polymer coatings also demonstrate low cytotoxicity and good hemocompatibility. More importantly, s-EY-QEGED-CH3 significantly enhances in vivo therapeutic effects on an infected rat model. The present work provides an efficient strategy for the rational design of high-performance antibacterial materials to fight biomedical device-associated infections.
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